| http://purl.uniprot.org/citations/8839844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8839844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8839844 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid (RA)-induced maturation mediated by the retinoic acid receptor alpha (RAR alpha) has been implicated in myeloid development. We have used differential hybridization analysis of a cDNA library constructed from the murine RA-inducible MPRO promyelocyte cell line to identify immediate-early genes induced by RA during granulocytic differentiation. E3, one of nine sequences identified, was upregulated in an immediate-early manner, with transcript levels peaking after 60 minutes exposure to RA. E3 transcripts were RA-inducible in HL60 cells, but not in an RA-resistant subclone, HL60R, that harbors a mutated RAR alpha gene. However, when HL60R cells were transduced with a functional copy of the RAR alpha gene, RA induced a 10-fold increase in E3 mRNA levels. E3 transcripts are present in the myeloid, B-lymphoid, and erythroid lineages, absent in nonhematopoietic cells, and encode a highly hydrophobic, potentially phosphorylated polypeptide of unknown function with significant homology to a putative protein expressed in myeloid cells. The murine E3 promoter harbors a single bipartite retinoic acid response element which in transient transfection assays conferred RA sensitivity. These results indicate that E3 is a hematopoietic-specific gene that is an immediate target for the activated RAR alpha during myelopoiesis."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/author | "Scott L.M."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/author | "Scott L.M."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/author | "Mueller L."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/author | "Mueller L."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/author | "Collins S.J."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/author | "Collins S.J."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/pages | "2517-2530"xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/pages | "2517-2530"xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/title | "E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/title | "E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha."xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/8839844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8839844 |
| http://purl.uniprot.org/citations/8839844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8839844 |
| http://purl.uniprot.org/citations/8839844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8839844 |
| http://purl.uniprot.org/citations/8839844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8839844 |
| http://purl.uniprot.org/embl-cds/AAB53636.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8839844 |
| http://purl.uniprot.org/uniprot/Q61168 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8839844 |