| http://purl.uniprot.org/citations/8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8841202 | http://www.w3.org/2000/01/rdf-schema#comment | "Band 3 is the most abundant integral protein of the red blood cell membrane. It performs two critical biological functions: maintaining ionic homeostasis, by transporting Cl- and HCO3-ions, and providing mechanical stability to the erythroid membrane. Erythroid band 3 (AE1) is one of three anion exchangers that are encoded by separate genes. The AE1 gene is transcribed by two promoters: the upstream promoter produces erythroid band 3, whereas the downstream promoter initiates transcription of the band 3 isoform in kidney. To assess the biological consequences of band 3 deficiency, we have selectively inactivated erythroid but not kidney band 3 by gene targeting in mice. Although no death in utero occurred, the majority of homozygous mice die within two weeks after birth. The erythroid band 3 null mice show retarded growth, spherocytic red blood cell morphology and severe haemolytic anaemia. Remarkably, the band 3-/-red blood cells assembled normal membrane skeleton thus challenging the notion that the presence of band 3 is required for the stable biogenesis of membrane skeleton. The availability of band 3-/-mice offers a unique opportunity to investigate the role of erythroid band 3 in the regulation of membrane-skeletal interactions, anion transport and the invasion and growth of malaria parasite into red blood cells."xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1096-227"xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/author | "Chishti A.H."xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/author | "Yi S.J."xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/author | "Palek J."xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/author | "Southgate C.D."xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/author | "Mitchell B."xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/pages | "227-230"xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/title | "Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton."xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/8841202 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8841202 |
| http://purl.uniprot.org/citations/8841202 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8841202 |
| http://purl.uniprot.org/uniprot/P02730#attribution-EB13A3AF2FE340C3F090C0DE8A9D3442 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TZG9-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TZJ1-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_P04919-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TZ12-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TZ29-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TA19-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TAJ4-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TNH7-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |
| http://purl.uniprot.org/uniprot/#_Q3TNL6-mappedCitation-8841202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8841202 |