| http://purl.uniprot.org/citations/8843197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8843197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8843197 | http://www.w3.org/2000/01/rdf-schema#comment | "According to a model based on embryological studies in amphibia, dorsoventral patterning is regulated by the antagonizing function of ventralizing bone morphogenetic proteins (BMPs) and dorsalizing signals generated by Spemann's organizer. Large-scale mutant screens in the zebrafish, Danio rerio, have led to the isolation of two classes of recessive lethal mutations affecting early dorsoventral pattern formation. dino mutant embryos are ventralized, whereas swirl mutants are dorsalized. We show that at early gastrula stages, dino and swirl mutants display an expanded or reduced Bmp4 expression, respectively. The dino and swirl mutant phenotypes both can be phenocopied and rescued by the modulation of BMP signaling in wild-type and mutant embryos. By suppressing BMP signaling in dino mutants, adult fertile dino -/-fish were generated. These findings, together with results from the analysis of dino-swirl double mutants, indicate that dino fulfills its dorsalizing activity via a suppression of swirl-dependent, BMP-like ventralizing activities. Finally, cell transplantation experiments show that dino is required on the dorsal side of early gastrula embryos and acts in a non-cell-autonomous fashion. Together, these results provide genetic evidence in support of a mechanism of early dorsoventral patterning that is conserved among vertebrate and invertebrate embryos."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.10.19.2452"xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/author | "Hammerschmidt M."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/author | "Hammerschmidt M."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/author | "McMahon A.P."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/author | "McMahon A.P."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/author | "Serbedzija G.N."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/author | "Serbedzija G.N."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/pages | "2452-2461"xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/pages | "2452-2461"xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/title | "Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/title | "Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor."xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/8843197 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8843197 |
| http://purl.uniprot.org/citations/8843197 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8843197 |
| http://purl.uniprot.org/citations/8843197 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8843197 |
| http://purl.uniprot.org/citations/8843197 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8843197 |
| http://purl.uniprot.org/uniprot/Q90265 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8843197 |