http://purl.uniprot.org/citations/8849351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8849351 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo describe the histopathologic and biochemical characteristics of skin from the Tsk2/+ mouse, a mutation with phenotypic features resembling those of systemic sclerosis (SSc), and to report the initial genetic mapping of the Tsk2 locus.MethodsHistologic examination was performed and collagen content and type I collagen messenger RNA (mRNA) levels were determined in skin biopsy specimens from Tsk2/+ mice and normal mice. An intersubspecific backcross was conducted as a first step toward identifying the position of the Tsk2 locus on mouse chromosome 1.ResultsHistologic examination of Tsk2/+ mouse skin revealed marked accumulation of collagen and infiltration with mononuclear cells in the dermis and adipose tissue. Biochemical studies of Tsk2/+ mouse skin showed increased collagen content and elevated steady-state levels of alpha 1 (I) procollagen mRNA. Tsk2 was mapped to a 15.3-centimorgan interval on mouse chromosome 1.ConclusionTsk2 is a novel mutation which displays histopathologic and biochemical abnormalities similar to those present in the skin of patients with SSc, including increased collagen content and expression of type I collagen genes. This mutation has been mapped to a 15.3-cM region on mouse chromosome 1. Further study of this novel mutation will allow the identification of previously undescribed mechanisms involved in the regulation of normal and pathologic collagen gene expression."xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.org/dc/terms/identifier | "doi:10.1002/art.1780381212"xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/author | "Peters J."xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/author | "Jimenez S.A."xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/author | "Siracusa L.D."xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/author | "Hawkins D."xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/author | "Christner P.J."xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/name | "Arthritis Rheum"xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/pages | "1791-1798"xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/title | "The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration."xsd:string |
http://purl.uniprot.org/citations/8849351 | http://purl.uniprot.org/core/volume | "38"xsd:string |
http://purl.uniprot.org/citations/8849351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8849351 |
http://purl.uniprot.org/citations/8849351 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8849351 |
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http://purl.uniprot.org/uniprot/#_Q3TVI5-mappedCitation-8849351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8849351 |
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