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http://purl.uniprot.org/citations/8855252http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8855252http://www.w3.org/2000/01/rdf-schema#comment"The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects."xsd:string
http://purl.uniprot.org/citations/8855252http://purl.org/dc/terms/identifier"doi:10.1073/pnas.93.20.10753"xsd:string
http://purl.uniprot.org/citations/8855252http://purl.uniprot.org/core/author"Skinner M.M."xsd:string
http://purl.uniprot.org/citations/8855252http://purl.uniprot.org/core/author"Terwilliger T.C."xsd:string
http://purl.uniprot.org/citations/8855252http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8855252http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/8855252http://purl.uniprot.org/core/pages"10753-10757"xsd:string
http://purl.uniprot.org/citations/8855252http://purl.uniprot.org/core/title"Potential use of additivity of mutational effects in simplifying protein engineering."xsd:string
http://purl.uniprot.org/citations/8855252http://purl.uniprot.org/core/volume"93"xsd:string
http://purl.uniprot.org/citations/8855252http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8855252
http://purl.uniprot.org/citations/8855252http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/8855252
http://purl.uniprot.org/uniprot/#_P69543-mappedCitation-8855252http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/8855252
http://purl.uniprot.org/uniprot/P69543http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/8855252