| http://purl.uniprot.org/citations/8862523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8862523 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of Syk kinase in Fc gamma receptor (Fc gamma R) IIA-mediated phagocytosis was examined with two forms of antisense oligodeoxynucleotides (ODNs) designed to hybridize to human Syk mRNA. Monocytes were incubated with linear and stem-loop antisense ODNs targeted to Syk mRNA. When complexed with cationic liposomes, stem-loop Syk antisense ODN with phosphorothioate modification exhibited stability in fetal bovine and human serum. The stem-loop Syk antisense ODN at a concentration of 0.2 microM inhibited Fc gamma RIIA-mediated phagocytosis by 90% and completely eliminated Syk mRNA and protein in monocytes, whereas scrambled-control ODNs had no effect. The Syk antisense ODNs did not change beta-actin mRNA levels and Fc gamma RII cell-surface expression. In addition, stem-loop Syk antisense ODN inhibited Fc gamma RI and Fc gamma RIIIA-mediated phagocytosis. These data indicate the efficacy of stem-loop Syk antisense ODN for targeting and degrading Syk mRNA and protein and the importance of Syk kinase in Fc gamma receptor-mediated phagocytosis. Immunoblotting assay demonstrated that Fc gamma RII tyrosine phosphorylation after Fc gamma RII cross-linking did not change in the absence of Syk protein. These results indicate that Syk kinase is required for Fc gamma RIIA-mediated phagocytic signaling and that Fc gamma RII cross-linking leads to tyrosine phosphorylation of Fc gamma RII independent of Syk kinase."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.7.7.1095"xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/author | "Wang D.C."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/author | "Park J.G."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/author | "Chien P."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/author | "Hunter S."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/author | "Schreiber A.D."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/pages | "1095-1106"xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/title | "Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides."xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/8862523 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8862523 |
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