| http://purl.uniprot.org/citations/8867815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8867815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8867815 | http://www.w3.org/2000/01/rdf-schema#comment | "The current report documents the molecular cloning of the mouse mitochondrial NADP-dependent isocitrate dehydrogenase (mNADP-IDH) cDNA. The cDNA was 1,863 bp in length and contained one open reading frame encoding a 523-residue polypeptide with a predicted molecular weight of 58 kDa. The cDNA and the deduced amino acid (AA) sequence of the mouse mNADP-IDH had a high degree of homology with those of porcine, bovine, alfalfa, and yeast. The recombinant mNADP-IDH expressed in Escherichia coli had active enzymatic function, as well as an expected molecular weight. The heart had the highest constitutive expression of the steady-state mNADP-IDH mRNA, followed by the kidney, while the expression of the gene in other tissues was low. The enzymatic activity of different tissues was in agreement with their mNADP-IDH mRNA levels. The resting lymphocytes had low constitutive expression of the gene, but the steady-state mRNA could be induced 48 h after mitogen stimulation. At the protein level, the resting lymphocytes had low enzymatic activity of mNADP-IDH, but the activity was augmented fivefold after mitogen stimulation. The cytosolic NADP-IDH, on the contrary, remained low or undetectable before and after the mitogen stimulation. Based on our current findings as well as the known roles of the mNADP-IDH in anabolism and in the isocitrate shuttle, it is conceivable that the mNADP-IDH is necessary for optimizing proliferation in lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-4644(19960301)60:3<400::aid-jcb11>3.0.co;2-o"xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-4644(19960301)60:3<400::aid-jcb11>3.0.co;2-o"xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Vinay P."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/author | "Vinay P."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/pages | "400-410"xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/pages | "400-410"xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/title | "Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent isocitrate dehydrogenase and the expression of the gene during lymphocyte activation."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/title | "Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent isocitrate dehydrogenase and the expression of the gene during lymphocyte activation."xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/8867815 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8867815 |
| http://purl.uniprot.org/citations/8867815 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8867815 |