| http://purl.uniprot.org/citations/8871629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8871629 | http://www.w3.org/2000/01/rdf-schema#comment | "Snell dwarf (dw/dw) mice are deficient in anterior pituitary hormones due to a mutation in the gene encoding the Pit-1 transcription factor. Bone marrow B cell development is also suppressed in the mice, providing circumstantial evidence that one or more anterior pituitary-derived products, or factors induced by them, are required for normal B lymphopoiesis. However, concluding that this is the case is dependent on showing that hormonal treatment of dwarf mice reverses their B cell defects. dw/dw mice were treated with growth hormone (GH), insulin-like growth factor-I (IGF-I), or thyroxine in an attempt to restore bone marrow B lymphopoiesis. GH and IGF-I increased the number of B lineage cells in the bone marrow and spleen but did not restore the frequency of bone marrow pre-B cells to normal. However, bone marrow cellularity in thyroxine-treated dw/dw mice was comparable to that in control animals, and both the frequency and absolute number of B lineage cells had increased to normal or even above normal. Taken together, these data indicate that endocrine factors, especially those regulated by the hypothalamic-pituitary-thyroid axis, are potent B lymphopoietic factors."xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/author | "Johnson A."xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/author | "Collins L."xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/author | "Clark R."xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/author | "Montecino-Rodriguez E."xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/author | "Dorshkind K."xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/pages | "3334-3340"xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/title | "Defective B cell development in Snell dwarf (dw/dw) mice can be corrected by thyroxine treatment."xsd:string |
| http://purl.uniprot.org/citations/8871629 | http://purl.uniprot.org/core/volume | "157"xsd:string |
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