| http://purl.uniprot.org/citations/8878534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8878534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8878534 | http://www.w3.org/2000/01/rdf-schema#comment | "A 4.7 kb cDNA of tyrosine phosphatase-like protein, phogrin, was isolated from a human islet cDNA library. Sequencing of the resulting clone identified a 3,045 residue open-reading frame encoding a 1,015 amino acid polypeptide with predicted molecular mass of 111,303 daltons. Phogrin's amino acid sequence has a single transmembrane region and one putative tyrosine phosphatase catalytic domain. Phogrin is 74% identical to the ICA512/IA-2 autoantigen of type 1 diabetes in the cytoplasmic domain, but only 29% in the luminal domain. It showed > 90% identity to rat phogrin and mouse IA-2 beta. Autoantibody radioassays utilizing full-length and the cytoplasmic domain of phogrin were compared. With positivity defined above the 99th percentile of 105 normal control subjects, 37 (48%) and 47 (61%) of sera from 77 new-onset patients with type 1 diabetes were positive for autoantibodies to full-length and the cytoplasmic domain of phogrin, respectively. The assay utilizing cytoplasmic human phogrin gave higher sensitivity with identical specificity to the assay utilizing the full-length molecule primarily due to lower "background" binding. Phogrin is an additional major autoantigen for type 1 diabetes and the isolation of the cDNA of this molecule from human islets will aid in studies of the pathogenesis of type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1996.1526"xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1996.1526"xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/author | "Hutton J.C."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/author | "Hutton J.C."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/author | "Eisenbarth G.S."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/author | "Eisenbarth G.S."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/author | "Kawasaki E."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/author | "Kawasaki E."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/pages | "440-447"xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/pages | "440-447"xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/title | "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/title | "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/volume | "227"xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://purl.uniprot.org/core/volume | "227"xsd:string |
| http://purl.uniprot.org/citations/8878534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8878534 |
| http://purl.uniprot.org/citations/8878534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8878534 |
| http://purl.uniprot.org/citations/8878534 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8878534 |
| http://purl.uniprot.org/citations/8878534 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8878534 |