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http://purl.uniprot.org/citations/8878687http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8878687http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8878687http://www.w3.org/2000/01/rdf-schema#comment"The mei-218 gene product is required for both meiotic crossing over and for the production of recombination modules, suggesting that these organelles are required for meiotic exchange. In this study the null phenotype of mei-218 was defined through the analysis of three preexisting and five new alleles. Consistent with previous studies, in homozygous mei-218 mutants meiotic crossing over is reduced to < 10% of normal levels. A molecular analysis of mei-218 was initiated with the isolation and mapping of lethal mutations and genome rearrangements in the region containing mei-218, polytene interval 15E on the X chromosome. This high resolution genetic map was aligned with a physical map constructed from cosmid and P1 clones by genetically mapping restriction fragment length polymorphisms and localizing rearrangement breakpoints. Within a region of 65 kb, we have identified seven transcription units, including mei-218 and the Minute(1)15D gene, which encodes ribosomal protein S5. The mei-218 mutant phenotype has been rescued by germline transformation with both a genomic fragment and a cDNA under the control of the hsp83 promoter. The mei-218 gene is predicted to produce an 1186-amino acid protein that has no significant similarities to any known proteins."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.org/dc/terms/identifier"doi:10.1093/genetics/144.1.215"xsd:string
http://purl.uniprot.org/citations/8878687http://purl.org/dc/terms/identifier"doi:10.1093/genetics/144.1.215"xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/author"McKim K.S."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/author"McKim K.S."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/author"Hawley R.S."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/author"Hawley R.S."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/author"Dahmus J."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/author"Dahmus J."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/name"Genetics"xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/name"Genetics"xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/pages"215-228"xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/pages"215-228"xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/title"Cloning of the Drosophila melanogaster meiotic recombination gene mei-218: a genetic and molecular analysis of interval 15E."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/title"Cloning of the Drosophila melanogaster meiotic recombination gene mei-218: a genetic and molecular analysis of interval 15E."xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/volume"144"xsd:string
http://purl.uniprot.org/citations/8878687http://purl.uniprot.org/core/volume"144"xsd:string
http://purl.uniprot.org/citations/8878687http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8878687
http://purl.uniprot.org/citations/8878687http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8878687
http://purl.uniprot.org/citations/8878687http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/8878687
http://purl.uniprot.org/citations/8878687http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/8878687