| http://purl.uniprot.org/citations/8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8887324 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila homeotic genes and vertebrate Hox genes are involved in the anteroposterior organization of the developing embryo. In Drosophila, the Polycomb- and trithorax-group genes are required to maintain the homeotic genes throughout development in the repressed or activated state, respectively. The murine Bmi-1 proto-oncogene was shown to exhibit homology to the Polycomb-group gene Posteior sex combs. Mice lacking the Bmi-1 gene revealed posterior transformations along the axial skeleton, whereas transgenic mice overexpressing Bmi-1 display anterior transformations. We have analysed the expression patterns of several Hox genes by RNA in situ hybridization on serial sections of 11.5- and 12.5-day Bmi-1 null mutant embryos. Furthermore, we have analysed the expression of a Hoxc-8/LacZ fusion gene in younger embryos. Our analyses show that Bmi-1 is involved in the repression of a subset of Hox genes from different clusters from at least day 9.5 onwards. We discuss the possibility that members of the murine Polycomb-group can form multimeric protein complexes of different compositions with varying affinity or specificity for different subsets of Hox genes."xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4773(96)00570-9"xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/author | "Deschamps J."xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/author | "van der Lugt N.M."xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/author | "Alkema M."xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/pages | "153-164"xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/title | "The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression."xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/8887324 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8887324 |
| http://purl.uniprot.org/citations/8887324 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8887324 |
| http://purl.uniprot.org/uniprot/P25916#attribution-66C42DE1F0B60ADA1F7459AD03B47F03 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J193-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_A0A087WR88-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_B2RWR0-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_A2ASR5-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_A2ASR6-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_A2ASR7-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_A2ASR8-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_B2RUB8-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_G3UZS1-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |
| http://purl.uniprot.org/uniprot/#_B9EI59-mappedCitation-8887324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8887324 |