| http://purl.uniprot.org/citations/8895560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8895560 | http://www.w3.org/2000/01/rdf-schema#comment | "Ectopic activation of the TAL-1 gene in T lymphocytes occurs in the majority of cases of human T cell acute lymphoblastic leukemia (T-ALL), yet experiments to date have failed to demonstrate a direct transforming capability for tal-1. The tal-1 gene product is a serine phosphoprotein and basic helix-loop-helix (bHLH) transcription factor known to regulate embryonic hematopoiesis. We have established a transgenic mouse model in which tal-1 mis-expression in the thymus results in the development of clonal T cell lymphoblastic leukemia/lymphoma. Thus, overexpression of tal-1 alone can be transforming, verifying its pathogenic role in human T-ALL. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of tal-1 and the catalytic subunit of casein kinase IIalpha (CKIIalpha), a serine/threonine protein kinase known to modulate the activity of other bHLH transcription factors. Although tal-1 is a substrate for CKII, the synergy of the tal-1 and CKIIalpha transgenes appears to be indirect, perhaps mediated through the E protein heterodimeric partners of tal-1. These studies prove that dysregulated tal-1 is oncogenic, providing a direct molecular explanation for the malignancies associated with TAL-1 activation in human T-ALL."xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1996.tb00900.x"xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/author | "Leder P."xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/author | "Seldin D.C."xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/author | "Kelliher M.A."xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/pages | "5160-5166"xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/title | "Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha."xsd:string |
| http://purl.uniprot.org/citations/8895560 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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