| http://purl.uniprot.org/citations/8896700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8896700 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study was made to investigate the ontogeny of protein gene-product 9.5 (PGP 9.5)-like immunoreactivity (-LI) in the developing mouse circumvallate papilla (CVP), and its distribution was compared to that of neuron-specific enolase (NSE) and calcitonin gene-related peptide (CGRP). In adult CVP, PGP 9.5-LI was observed in the subgemmal nerve plexus; some thin PGP 9.5-like immunoreactive (-IR) nerve fibers penetrated taste buds and apical epithelium. PGP 9.5-LI was also observed in the spindle-shaped cells in taste buds, and a small number of round- or oval-shaped ganglionic cells in the lamina propria. The distribution of NSE-LI was comparable to that of PGP 9.5-LI. CGRP-LI was observed in the nerve fibers only; distribution of CGRP-IR nerve fibers was similar to that of PGP 9.5-IR nerve fibers, although the number of CGRP-IR nerve fibers was smaller than that of PGP 9.5-IR nerve fibers. At least six developmental stages were defined with regard to the developmental changes in the distribution of PGP 9.5-LI from embryonic day (E) 12 to adulthood: Stage I (E12-13)-a dense nerve plexus of PGP 9.5-IR nerve fibers was detected in the lamina propria beneath the core of newly-formed papilla. Stage II (E14-16) - thin PGP 9.5-IR nerve fibers penetrated the apical epithelium, and a few round-shaped cells in the apical epithelium also displayed PGP 9.5-LI. Stage III (E17-18) - thin PGP 9.5-IR nerve fibers penetrated the inner lateral epithelium of the trench. Stage IV [Postnatal day (P) 0-3] - many PGP 9.5-IR nerve fibers penetrated the outer lateral epithelium of the trench; later in this stage, taste buds appeared. Stage V (P5-10) - a small number of PGP 9.5-IR cells in the taste buds appeared, and their number increased gradually. Stage VI (P14-adult) - the number of PGP 9.5-IR taste cells increased and reached the adult level, while the number of PGP 9.5-IR nerve fibers decreased. The development of NSE-LI was similar to that of PGP 9.5-LI. CGRP-IR nerve fibers were detected at E12 in the lamina propria, and the development of the intraepithelial CGRP-IR nerve fibers was similar to that of PGP 9.5-IR nerve fibers. The present results indicate that invasion by nerve fibers of the epithelium of lingual papillae occurs in a complex manner, and that these nerve fibers may participate in the formation of the taste buds."xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00198538"xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/author | "Kato J."xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/author | "Kurisu K."xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/author | "Miyawaki Y."xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/author | "Youn S.H."xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/author | "Wakisaka S."xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/name | "Anat Embryol (Berl)"xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/pages | "365-372"xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/title | "Protein gene-product 9.5 in developing mouse circumvallate papilla: comparison with neuron-specific enolase and calcitonin gene-related peptide."xsd:string |
| http://purl.uniprot.org/citations/8896700 | http://purl.uniprot.org/core/volume | "194"xsd:string |
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