| http://purl.uniprot.org/citations/8898193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8898193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8898193 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER-resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway, the unfolded protein response (UPR). We have identified a basic-leucine zipper transcription factor, Hac1p, that is required for the UPR and binds to the UPR element in the promoter of UPR-regulated genes. Surprisingly, Hac1p is found in UPR-activated cells only, and its level is controlled by regulated splicing of its mRNA. Splicing replaces the C-terminal tail of Hac1p with a different peptide that renders Hac1p more resistant to an otherwise extremely rapid ubiquitin-dependent degradation. We propose that the complex regulation of Hac1p expression serves to provide multiple levels at which the UPR can be controlled."xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81360-4"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81360-4"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/author | "Cox J.S."xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/author | "Cox J.S."xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/author | "Walter P."xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/author | "Walter P."xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/pages | "391-404"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/pages | "391-404"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/title | "A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response."xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/title | "A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response."xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/8898193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8898193 |
| http://purl.uniprot.org/citations/8898193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8898193 |
| http://purl.uniprot.org/citations/8898193 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8898193 |
| http://purl.uniprot.org/citations/8898193 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8898193 |
| http://purl.uniprot.org/uniprot/P41546 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8898193 |
| http://purl.uniprot.org/uniprot/P41546#attribution-FEC0D2B2518DC2C7C846069397520C93 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8898193 |