| http://purl.uniprot.org/citations/8898221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8898221 | http://www.w3.org/2000/01/rdf-schema#comment | "The par genes participate in the process of establishing cellular asymmetries during the first cell cycle of Caenorhabditis elegans development. The par-2 gene is required for the unequal first cleavage and for asymmetries in cell cycle length and spindle orientation in the two resulting daughter cells. We have found that the PAR-2 protein is present in adult gonads and early embryos. In gonads, the protein is uniformly distributed at the cell cortex, and this subcellular localization depends on microfilaments. In the one-cell embryo, PAR-2 is localized to the posterior cortex and is partitioned into the posterior daughter, P1, at the first cleavage. PAR-2 exhibits a similar asymmetric cortical localization in P1, P2, and P3, the asymmetrically dividing blastomeres of germ line lineage. This distribution in embryos is very similar to that of PAR-1 protein. By analyzing the distribution of the PAR-2 protein in various par mutant backgrounds we found that proper asymmetric distribution of PAR-2 depends upon par-3 activity but not upon par-1 or par-4. par-2 activity is required for proper cortical localization of PAR-1 and this effect requires wild-type par-3 gene activity. We also find that, although par-2 activity is not required for posterior localization of P granules at the one-cell stage, it is required for proper cortical association of P granules in P1."xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.122.10.3075"xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/author | "Boyd L."xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/author | "Guo S."xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/author | "Kemphues K.J."xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/author | "Levitan D."xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/author | "Stinchcomb D.T."xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/pages | "3075-3084"xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/title | "PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/8898221 | http://purl.uniprot.org/core/volume | "122"xsd:string |
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