| http://purl.uniprot.org/citations/8910362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8910362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8910362 | http://www.w3.org/2000/01/rdf-schema#comment | "The heterogeneous nuclear ribonucleoprotein particle (hnRNP) K protein is comprised of multiple modular domains that serve to engage a diverse group of molecular partners including DNA, RNA, the product of the proto-oncogene vav, and tyrosine and serine/threonine kinases. To identify additional K protein molecular partners and to further understand its function, we used a fragment of K protein as a bait in the yeast two-hybrid screen. The deduced primary structure of one of the positive clones revealed a novel zinc finger protein, hereby denoted as Zik1. In addition to the nine contiguous zinc fingers in the C terminus, Zik1 contains a KRAB-A domain thought to be involved in transcriptional repression. Zik1 and K protein bound in vitro and co-immunoprecipitated from cell extracts indicating that in vivo their interaction is direct. Expression of Gal4 DNA-binding domain-Zik1 fusion protein repressed a gene promoter bearing Gal4-binding elements, indicating that from cognate DNA elements Zik1 is a transcriptional repressor. The known diverse nature of K protein molecular interactions and now the identification of a K protein partner that is a transcriptional repressor lends support to the notion that K protein is a remarkably versatile molecule that may be acting as a docking platform to facilitate communication among molecules involved in signal transduction and gene expression."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.44.27701"xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.44.27701"xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "O'Neill B."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "O'Neill B."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Ostrowski J."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Ostrowski J."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Bomsztyk K."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Bomsztyk K."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Denisenko O.N."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Denisenko O.N."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Van Seuningen I."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/author | "Van Seuningen I."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/pages | "27701-27706"xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/pages | "27701-27706"xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/title | "Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/title | "Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein."xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/8910362 | http://purl.uniprot.org/core/volume | "271"xsd:string |