| http://purl.uniprot.org/citations/8913769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8913769 | http://www.w3.org/2000/01/rdf-schema#comment | "Both natural selection and mutational biases contribute to variation in codon usage bias within Drosophila species. This study addresses the cause of codon bias differences between the sibling species, Drosophila melanogaster and D. simulans. Under a model of mutation-selection-drift, variation in mutational processes between species predicts greater base composition differences in neutrally evolving regions than in highly biased genes. Variation in selection intensity, however, predicts larger base composition differences in highly biased loci. Greater differences in the G+C content of 34 coding regions than 46 intron sequences between D. melanogaster and D. simulans suggest that D. melanogaster has undergone a reduction in selection intensity for codon bias. Computer simulations suggest at least a fivefold reduction in Nes at silent sites in this lineage. Other classes of molecular change show lineage effects between these species. Rates of amino acid substitution are higher in the D. melanogaster lineage than in D. simulans in 14 genes for which outgroup sequences are available. Surprisingly, protein sizes are larger in D. melanogaster than in D. simulans in the 34 genes compared between the two species. A substantial fraction of silent, replacement, and insertion/deletion mutations in coding regions may be weakly selected in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/8913769 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/144.3.1297"xsd:string |
| http://purl.uniprot.org/citations/8913769 | http://purl.uniprot.org/core/author | "Akashi H."xsd:string |
| http://purl.uniprot.org/citations/8913769 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8913769 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/8913769 | http://purl.uniprot.org/core/pages | "1297-1307"xsd:string |
| http://purl.uniprot.org/citations/8913769 | http://purl.uniprot.org/core/title | "Molecular evolution between Drosophila melanogaster and D. simulans: reduced codon bias, faster rates of amino acid substitution, and larger proteins in D. melanogaster."xsd:string |
| http://purl.uniprot.org/citations/8913769 | http://purl.uniprot.org/core/volume | "144"xsd:string |
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