| http://purl.uniprot.org/citations/8923208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8923208 | http://www.w3.org/2000/01/rdf-schema#comment | "In Saccharomyces cerevisiae, the YPT6 gene encodes the homologue of the mammalian Rab6 protein found in the Golgi apparatus. Deletion of YPT6 in yeast produces a phenotype showing temperature-sensitive growth and partial missorting of the vacuolar enzyme, carboxypeptidase Y. To identify proteins that might: (1) interact with Ypt6p; or (2) act in the same pathway, we have isolated four multicopy suppressors, named SYS1, SYS2, SYS3 and SYS5, that can complement the temperature-sensitive growth phenotype of the ypt6 null mutant. On high expression, these genes are also able to partially suppress the missorting of carboxypeptidase Y.SYS2 on a multicopy plasmid suppresses in addition the temperature-sensitive phenotype of sec7-1, a mutant defective in transport between and from the Golgi compartment. Gene disruption of SYS1 and SYS2 did not result in significant growth defects. However, deletion of SYS1 and/or SYS2 in the ypt6 null mutant enhances defects in vacuolar protein sorting and in cell growth. Whereas protein secretion was not significantly affected in these mutants, the processing of alpha-factor precursor by the Kex2 protease was inhibited, suggesting a function of YPT6 and its null mutant suppressors in transport between the late Golgi and a prevacuolar, endosome-like compartment."xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.109.10.2471"xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://purl.uniprot.org/core/author | "Gallwitz D."xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://purl.uniprot.org/core/author | "Tsukada M."xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8923208 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://purl.uniprot.org/core/pages | "2471-2481"xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://purl.uniprot.org/core/title | "Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p."xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/8923208 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8923208 |
| http://purl.uniprot.org/citations/8923208 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8923208 |
| http://purl.uniprot.org/uniprot/P41544#attribution-C124004D4649819F154B030FDE9B4F60 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/Q99260#attribution-8AD4086B8984A444C22FEB735C002624 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/#_P41544-mappedCitation-8923208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/#_Q06704-mappedCitation-8923208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/#_P25567-mappedCitation-8923208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/#_Q99260-mappedCitation-8923208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/P25567 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/Q06704 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/Q99260 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8923208 |
| http://purl.uniprot.org/uniprot/P41544 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8923208 |