| http://purl.uniprot.org/citations/8924213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8924213 | http://www.w3.org/2000/01/rdf-schema#comment | "The enzyme 3 beta-hydroxysteroid dehydrogenase (3 betaHSD) is essential for all steroid hormone biosynthesis. Six distinct 3 betaHSD cDNAs in the mouse (3 betaHSD I-VI) have been isolated previously. This study reports the isolation of genes or partial genes encoding the 3 betaHSDI, II, III, and IV isoforms. Characterization of the genes revealed that they consist of four exons, the same structure that has been observed for characterized human 3 betaHSD genes. Primer extension and nuclease S1 analysis identified the start sites of transcription of Hsd3b -1 and -4. The proximal promoter regions of Hsd3b-1 and -4 were sequenced and putative cis-acting sequences were determined. Previously, we reported that the then known 3 betaHSD genes (3 betaHSD I-IV) were located in a small region of mouse chromosome 3. To analyze this locus further, six yeast artificial chromosome clones containing the 3 betaHSD sequence were identified. One clone appears to contain the complete 3 betaHSD locus within its 1,400-kbp insert. Further analysis of this YAC, along with analysis of mouse genomic DNA by pulsed-field gel electrophoresis, suggests all members of the 3 betaHSD gene family may be contained on a 400-kbp fragment."xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.org/dc/terms/identifier | "doi:10.1089/dna.1996.15.387"xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/author | "Bain P.A."xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/author | "Clarke T.R."xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/author | "Payne A.H."xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/author | "Burmeister M."xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/name | "DNA Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/pages | "387-399"xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/title | "Isolation and characterization of several members of the murine Hsd3b gene family."xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/8924213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8924213 |
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| http://purl.uniprot.org/uniprot/#_B1ARP0-mappedCitation-8924213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8924213 |
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