| http://purl.uniprot.org/citations/8928820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8928820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8928820 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein B (SP-B) is essential for physiological function of pulmonary surfactant. In the present investigation, we isolated rabbit SP-B gene and determined its nucleotide sequence, transcription start site, and exon/intron organization. The coding region of rabbit SP-B gene is comprised of 6.8 kb of sequence and is organized into 10 introns and 11 exons. By deletion analysis we determined that a region of SP-B gene extending from -236 to +39 nucleotides is sufficient for high-level expression of CAT reporter gene in a cell type-specific manner in the pulmonary adenocarcinoma cell line NCI-H441. Deletion of 5'-flanking sequence to -140 and -71 nucleotides significantly reduced SP-B promoter activity, suggesting that the -236 to +39 region contains cis-DNA elements required for cell type-specific expression. The proximal promoter region of SP-B gene contained DNA sequence motifs for binding thyroid transcription factor 1 (TTF-1) (-113 to -97) and hepatocyte nuclear factor 3(HNF-3) (-91 to -81). Although SP-B gene sequence -140 to +39 did not support high level expression of CAT gene in NCI-H441 cells, it was capable of activation by TTF-1 in HeLa cells, suggesting that the -236 to -140 sequence plays an important role in cell type-specific activation of SP-B promoter."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.1996.270.4.l601"xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.1996.270.4.l601"xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/author | "Boggaram V."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/author | "Boggaram V."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/author | "Margana R.K."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/author | "Margana R.K."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/pages | "L601-L612"xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/pages | "L601-L612"xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/title | "Rabbit surfactant protein B gene: structure and functional characterization of the promoter."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/title | "Rabbit surfactant protein B gene: structure and functional characterization of the promoter."xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/8928820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8928820 |
| http://purl.uniprot.org/citations/8928820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8928820 |
| http://purl.uniprot.org/citations/8928820 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8928820 |
| http://purl.uniprot.org/citations/8928820 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8928820 |
| http://purl.uniprot.org/embl-cds/AAB48076.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8928820 |
| http://purl.uniprot.org/uniprot/P15285 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8928820 |