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http://purl.uniprot.org/citations/8939607http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8939607http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8939607http://www.w3.org/2000/01/rdf-schema#comment"

Background

One way of establishing a morphogen gradient in a developing embryo involves the localized synthesis of an inducing molecule followed by its diffusion into surrounding tissues. The morphogen-like effects of the mesoderm-inducing factor activin provide support for this idea in amphibian development. The questions remain, however, of how activin exerts its long-range effects, and whether long-range signalling is a property of all transforming growth factor beta (TGF-beta) family members.

Results

We compare the signalling ranges of activin and two other TGF-beta family members, Xnr-2 and BMP-4. Unlike activin, Xnr-2 and BMP-4 act over short distances. Furthermore, the effects of constitutively active activin receptors are strictly cell-autonomous. These observations suggest that the long-range effects of activin occur through protein diffusion and that "relay' mechanisms are not initiated by any of these TGF-beta family members. Mechanisms limiting the signalling range of Xnr-2 were addressed by studying Xnr-2 processing and secretion. An activin-Xnr-2 fusion protein signals over many cell diameters, suggesting that regulated processing or secretion is one limiting factor. Disaggregation and reaggregation of Xnr-2-producing tissues also extends the range of Xnr-2, suggesting that components of intact tissue restrict spread of the protein.

Conclusions

The long-range effects of activin are likely to occur through the diffusion of activin protein. The short-range effects of Xnr-2 and BMP-4 emphasize that long-range diffusion is not a general property of TGF-beta-related molecules. Finally, signalling ranges may be regulated by constraints on processing or secretion and by interactions with extracellular components of embryonic tissues."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.org/dc/terms/identifier"doi:10.1016/s0960-9822(96)00751-8"xsd:string
http://purl.uniprot.org/citations/8939607http://purl.org/dc/terms/identifier"doi:10.1016/s0960-9822(96)00751-8"xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/author"Jones C.M."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/author"Jones C.M."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/author"Smith J.C."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/author"Smith J.C."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/author"Armes N."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/author"Armes N."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/name"Curr. Biol."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/name"Curr. Biol."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/pages"1468-1475"xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/pages"1468-1475"xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/title"Signalling by TGF-beta family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/title"Signalling by TGF-beta family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin."xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/volume"6"xsd:string
http://purl.uniprot.org/citations/8939607http://purl.uniprot.org/core/volume"6"xsd:string
http://purl.uniprot.org/citations/8939607http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8939607
http://purl.uniprot.org/citations/8939607http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8939607
http://purl.uniprot.org/citations/8939607http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/8939607
http://purl.uniprot.org/citations/8939607http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/8939607
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