RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/8943317http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8943317http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8943317http://www.w3.org/2000/01/rdf-schema#comment"Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4, encoding a WD-40 repeat protein, and CDC34, encoding a ubiquitin-conjugating enzyme, are involved in the destruction of these regulators. Here we describe evidence indicating that CDC53 also is involved in this process. Mutations in CDC53 cause a phenotype indistinguishable from those of cdc4 and cdc34 mutations, numerous genetic interactions are seen between these genes, and the encoded proteins are found physically associated in vivo. Cdc53p defines a large family of proteins found in yeasts, nematodes, and humans whose molecular functions are uncharacterized. These results suggest a role for this family of proteins in regulating cell cycle proliferation through protein degradation."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.org/dc/terms/identifier"doi:10.1128/mcb.16.12.6634"xsd:string
http://purl.uniprot.org/citations/8943317http://purl.org/dc/terms/identifier"doi:10.1128/mcb.16.12.6634"xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Johnson S.L."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Johnson S.L."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Pringle J.R."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Pringle J.R."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Winey M."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Winey M."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Byers B."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Byers B."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Adams A.E."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Adams A.E."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Goebl M.G."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Goebl M.G."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Goetsch L."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Goetsch L."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Mathias N."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/author"Mathias N."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/name"Mol. Cell. Biol."xsd:string
http://purl.uniprot.org/citations/8943317http://purl.uniprot.org/core/name"Mol. Cell. Biol."xsd:string