| http://purl.uniprot.org/citations/8943331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8943331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8943331 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein tyrosine kinase ZAP-70 plays an essential role in T-cell activation and development. After T-cell receptor stimulation, ZAP-70 is associated with the receptor and is phosphorylated on many tyrosine residues, including tyrosine 292 (Y-292), in the region between the C-terminal SH2 domain and the kinase domain (interdomain B). Here we show that a mutation of Y-292 (292F) or deletion of interdomain B enhanced the ability of ZAP-70 to reconstitute B-cell receptor stimulation-dependent NF-AT induction in a B-cell line deficient in Syk. In contrast, in a T-cell line, expression of 292F led to basal NF-AT induction independent of T-cell receptor stimulation. These results demonstrate that the role of Y-292 is to negatively regulate the function of ZAP-70 in lymphocytes. This appears to be a dominant function of interdomain B because deletion of most of interdomain B also resulted in a mutant of ZAP-70 with enhanced ability to reconstitute Syk-deficient DT-40 B cells. Since our biochemical studies did not reveal an effect of the 292F mutation on either the kinase activity of ZAP-70 or on the ability of ZAP-70 to bind to the receptor, we propose a model in which Y-292 interacts with an inhibitory protein to negatively regulate ZAP-70 function."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.16.12.6765"xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.16.12.6765"xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/pages | "6765-6774"xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/pages | "6765-6774"xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/title | "Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/title | "Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70."xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/8943331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8943331 |
| http://purl.uniprot.org/citations/8943331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8943331 |
| http://purl.uniprot.org/citations/8943331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8943331 |
| http://purl.uniprot.org/citations/8943331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8943331 |
| http://purl.uniprot.org/uniprot/P43403 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8943331 |
| http://purl.uniprot.org/uniprot/P43403#attribution-78FA4E6B99199370C8736F068A21B5BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8943331 |