| http://purl.uniprot.org/citations/8945508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8945508 | http://www.w3.org/2000/01/rdf-schema#comment | "Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal tumorigenisis, we determined the effects of COX-2 gene (Ptgs2) knockouts and a novel COX-2 inhibitor on Apc delta716 knockout mice, a model of human familial adenomatous polyposis. A Ptgs2 null mutation reduced the number and size of the intestinal polyps dramatically. Furthermore, treating Apc delta716 mice with a novel COX-2 inhibitor reduced the polyp number more significantly than with sulindac, which inhibits both isoenzymes. These results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COX-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81988-1"xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Oshima M."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Evans J.F."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Dinchuk J.E."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Trzaskos J.M."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Oshima H."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Kwong E."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Hancock B."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/author | "Kargman S.L."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/pages | "803-809"xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/title | "Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)."xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/8945508 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8945508 |
| http://purl.uniprot.org/citations/8945508 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8945508 |
| http://purl.uniprot.org/uniprot/Q61315#attribution-6372736980491CCD537FBF8C86B5115C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8945508 |
| http://purl.uniprot.org/uniprot/Q05769#attribution-CD4A17DD78FFFA731B9AF8B53472179B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8945508 |
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| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-8945508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8945508 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-8945508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8945508 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-8945508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8945508 |