| http://purl.uniprot.org/citations/8951039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8951039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8951039 | http://www.w3.org/2000/01/rdf-schema#comment | "A 2432-bp cDNA for mouse FAD-linked glycerol-3-phosphate dehydrogenase, a nuclear-encoded enzyme associated with the inner mitochondrial membrane, was isolated from a Lambda ZAP phage library generated from brown adipocyte mRNA. The amino acid sequence was 95 and 93% homologous to the rat and human enzymes. PvuII and SacI polymorphisms between Mus spretus and C57BL/6J were used to map the mouse FAD-linked glycerol-3-phosphate dehydrogenase gene (Gdm1) to chromosome 2, 33 cM from the centromere. Northern blot analysis showed that brown adipose tissue predominantly expressed a 6.5-kb mRNA with lower expression of 4.5- and 2.4-kb forms, whereas brain and pancreatic islets almost exclusively expressed a 6.5-kb transcript, muscle expressed a 4.5-kb transcript, and testis expressed a 2.4-kb RNA form. Analysis of poly(A)+ RNA from brown adipose tissue suggested that all RNA forms are polyadenylated. Among the tissues examined, FAD-linked glycerol-3-phosphate dehydrogenase protein levels and enzyme activity were highest in brown adipose tissue, and a consistent correlation between protein levels and enzyme activity in all tissues was observed. RNA levels corresponded to protein levels in all tissues except testis, where high levels of 2.4-kb mRNA and relatively low protein were expressed. Exposing mice to cold temperatures induced the 6.5-kb mRNA and enzyme activity only in brown adipose tissue, suggesting a role for thermogenesis in this tissue. Although the molecular basis for the formation of the 6.5- and 4.5-kb mRNA's is not known, data suggest that the regulation of FAD-linked glycerol-3-phosphate dehydrogenase is complex and tissue-specific."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.org/dc/terms/identifier | "doi:10.1006/abbi.1996.0536"xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.org/dc/terms/identifier | "doi:10.1006/abbi.1996.0536"xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Leiter E.H."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Leiter E.H."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Brown L.J."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Brown L.J."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Macdonald M.J."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Macdonald M.J."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Kozak L.P."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Kozak L.P."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Koza R.A."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Koza R.A."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Kozak U.C."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/author | "Kozak U.C."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/name | "Arch. Biochem. Biophys."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/name | "Arch. Biochem. Biophys."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/pages | "97-104"xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/pages | "97-104"xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/title | "Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase."xsd:string |
| http://purl.uniprot.org/citations/8951039 | http://purl.uniprot.org/core/title | "Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase."xsd:string |