| http://purl.uniprot.org/citations/8955070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8955070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8955070 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenesis, or the formation of new blood vessels, plays a central role in a number of physiologic and pathologic conditions, including wound healing, diabetic retinopathy, and solid tumor growth, and endothelial cells can be induced to mimic this process in vitro. Using a modification of the differential display method (Zimrin, A. B., Villeponteau, B., and Maciag, T. (1995) Biochem. Biophys. Res. Commun. 213, 630-638), we isolated the human homolog of the Jagged ligand for the Notch receptor from human endothelial cells exposed to fibrin and demonstrate that the Jagged transcript, but not the Notch 1 or Notch 2 transcripts, are up-regulated by fibrin. Interestingly, the addition of an antisense Jagged oligomer to bovine microvascular endothelial cells grown on a collagen gel resulted in a marked increase in invasion and tube formation in the underlying gel in response to fibroblast growth factor. In contrast, no effect was observed on vascular endothelial growth factor-induced angiogenesis under identical conditions. These data suggest that Jagged-Notch signaling is able to regulate fibroblast growth factor-induced endothelial cell migration in vitro, an early event during angiogenesis in vivo."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.51.32499"xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.51.32499"xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Pepper M.S."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Pepper M.S."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Maciag T."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Maciag T."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Montesano R."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Montesano R."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Nguyen F."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Nguyen F."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Zimrin A.B."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "Zimrin A.B."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "McMahon G.A."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/author | "McMahon G.A."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/pages | "32499-32502"xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/pages | "32499-32502"xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/title | "An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro."xsd:string |
| http://purl.uniprot.org/citations/8955070 | http://purl.uniprot.org/core/title | "An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro."xsd:string |