| http://purl.uniprot.org/citations/8962093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8962093 | http://www.w3.org/2000/01/rdf-schema#comment | "The Gfi-1 protooncogene encodes a nuclear zinc-finger protein that carries a novel repressor domain, SNAG, and functions as a position- and orientation-independent active transcriptional repressor. The Gfi-1 repressor allows interleukin 2 (IL-2)-dependent T cells to escape G1 arrest induced by IL-2 withdrawal in culture and collaborates with c-myc and pim-1 for the induction of retrovirus-induced lymphomas in animals. Here we show that overexpression of Gfi-1 also inhibits cell death induced by cultivation of IL-2-dependent T-cell lines in IL-2-deficient media. Similarly, induction of Gfi-1 in primary thymocytes from mice carrying a metal-inducible Gfi-1 transgene inhibits cell death induced by cultivation in vitro. The protein and mRNA levels of the proapoptotic regulator Bax are down-regulated by Gfi-1 in both immortalized T-cell lines and primary transgenic thymocytes. The repression is direct and depends on several Gfi-1-binding sites in the p53-inducible Bax promoter. In addition to Bax, Gfi-1 also represses Bak, another apoptosis-promoting member of the Bcl-2 gene family. Therefore, Gfi-1 may inhibit apoptosis by means of its repression of multiple proapoptotic regulators. The antiapoptotic properties of Gfi-1 provide a potential explanation for its strong collaboration with c-myc during oncogenesis."xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.25.14569"xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/author | "Grimes H.L."xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/author | "Gilks C.B."xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/author | "Chan T.O."xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/author | "Porter S."xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/pages | "14569-14573"xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/title | "The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death."xsd:string |
| http://purl.uniprot.org/citations/8962093 | http://purl.uniprot.org/core/volume | "93"xsd:string |
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