| http://purl.uniprot.org/citations/8977288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8977288 | http://www.w3.org/2000/01/rdf-schema#comment | "Collagen-induced arthritis (CIA) is an animal model for rheumatoid arthritis. The disease is elicited by immunization of genetically susceptible DBA/1 mice with type II collagen, resulting in a debilitating arthritis characterized by inflammation and involvement of multiple joints. We investigated the role of endogenous interleukin (IL)-12 in the pathogenesis of this disease by undertaking an analysis of IL-12-deficient mice on the DBA/1 genetic background after immunization with type II collagen. Both the incidence and severity of disease were significantly reduced in mice unable to produce biologically active IL-12. Concomitant decreases were observed in serum levels of pathogenic, collagen-specific IgG2a antibodies and collagen-induced secretion of interferon-gamma by immune splenocytes in vitro, consistent with an impaired T helper-1 response. There were, however, a few animals which developed severe disease in a single paw in spite of this highly diminished Th1 response. Taken together, these results demonstrate an important role for IL-12 in the pathogenesis of CIA, although it is not absolutely required for disease development."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.1830261219"xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Magram J."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Gately M.K."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Warrier R.R."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Connaughton S.E."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Shuster D.J."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Arp L.H."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Gillooly K.M."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "Hall L.B."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/author | "McIntyre K.W."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/pages | "2933-2938"xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/title | "Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/8977288 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8977288 |
| http://purl.uniprot.org/citations/8977288 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8977288 |
| http://purl.uniprot.org/uniprot/#_F8WI71-mappedCitation-8977288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8977288 |
| http://purl.uniprot.org/uniprot/#_Q3ZAX5-mappedCitation-8977288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8977288 |
| http://purl.uniprot.org/uniprot/#_P43431-mappedCitation-8977288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8977288 |
| http://purl.uniprot.org/uniprot/#_P43432-mappedCitation-8977288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8977288 |
| http://purl.uniprot.org/uniprot/#_Q549G3-mappedCitation-8977288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8977288 |
| http://purl.uniprot.org/uniprot/#_Q9QUT1-mappedCitation-8977288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8977288 |