| http://purl.uniprot.org/citations/8982507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8982507 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present study was to characterize pharmacologically endothelin receptors that are present in human umbilical vessels. 2. Endothelin-1 (ET-1) and endothelin-2 (ET-2) are potent stimulants of both the human umbilical artery (pEC50 7.9 and 7.5) and vein (pEC50 8.1 and 8.0). Endothelin-3 (ET-3) is inactive on the artery but contracts the vein (pEC50 7.6). IRL1620 is inactive in both vessels. The order of potency of agonists is suggestive of a typical ET(A) receptor in the artery (ET-1 = ET-2 > > ET-3) and a mixture of ET(A) and ET(B) receptors in the vein (ET-1 = ET-2 > or = ET-3). 3. The selective ET(A) receptor antagonist, BQ123, competitively inhibits the effect of ET-1 in the human umbilical artery (pA2 6.9), while in the vein, only a mixture of BQ123 and BQ788 (a selective ET(B) antagonist) weakly displaces to the right of the cumulative concentration-response curve to ET-1. Contractions induced by ET-3 in the vein are inhibited by BQ788 (pA2 7.6), but not by BQ123. 4. Inhibition of Ca2+ channels by nifedipine (0.1 microM) is accompanied by a significant decrease of the maximal response to ET-1 by 40% in the artery and by 30% in the vein. The response of the vein to ET-3 is almost abolished by nifedipine. 5. The results indicate that: (i) endothelins contract the human isolated umbilical artery via stimulation of an ET(A) receptor type; (ii) the contraction induced by ET-1 in the vein is mediated by both ET(A) and ET(B) receptors, while ET-3 stimulates the ET(B) receptor; (iii) the contribution of Ca2+ channels to the contraction mediated by the ET(B) receptor appears to be more important than to that mediated by the ET(A) receptor."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1476-5381.1996.tb16078.x"xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/author | "Rizzi A."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/author | "Calo G."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/author | "Regoli D."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/author | "Campobasso C."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/author | "D'Orleans-Juste P."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/author | "Bogoni G."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/name | "Br J Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/pages | "1600-1604"xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/title | "Characterization of endothelin receptors in the human umbilical artery and vein."xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/8982507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8982507 |
| http://purl.uniprot.org/citations/8982507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8982507 |
| http://purl.uniprot.org/uniprot/P20800#attribution-CC60333C80181939D9B9F99E293D9ACC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8982507 |
| http://purl.uniprot.org/uniprot/P05305#attribution-CC60333C80181939D9B9F99E293D9ACC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8982507 |
| http://purl.uniprot.org/uniprot/P25101#attribution-B8A7F5CA685D9E050211B29BF3D07CDC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8982507 |
| http://purl.uniprot.org/uniprot/P14138#attribution-CC60333C80181939D9B9F99E293D9ACC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8982507 |
| http://purl.uniprot.org/uniprot/P24530#attribution-B8A7F5CA685D9E050211B29BF3D07CDC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8982507 |