| http://purl.uniprot.org/citations/8992987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8992987 | http://www.w3.org/2000/01/rdf-schema#comment | "N region diversity in Ag receptors is a developmentally regulated process in B and T cells that correlates with the differential expression of terminal deoxynucleotidyl transferase (TdT). Absent in fetal and newborn mice, TdT expression is restricted to early T and pro-B cells in adults. To extend the TdT expression pattern throughout B cell ontogenesis, we generated transgenic mice carrying a TdT cDNA under the regulatory elements of the N-myc gene and the IgH enhancer. High expression was observed in secondary lymphoid organs consistent with TdT activity beyond the pre-B cell stage. This suggests that TdT transgene expression is not down-regulated as is the endogenous gene. Unlike normal mice, extensive N region diversity was found in rearranged lambda light chain genes of adult transgenic animals. Therefore, expression of TdT appears sufficient for N region diversity to occur at any Ig locus. More importantly, expression of the transgene takes place during fetal development. As a consequence, the potential fetal B cell repertoire is modified as both rearranged heavy and light chain genes now show N region additions. Constitutive expression of TdT throughout B cell differentiation does not therefore appear deleterious and suggests that TdT is recruited only to participate in the V(D)J recombination process."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/author | "Rougeon F."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/author | "Bentolila L.A."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/author | "Wu G.E."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/author | "Doyen N."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/author | "Fanton d'Andon M."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/author | "Nourrit F."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/pages | "715-723"xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/title | "Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://purl.uniprot.org/core/volume | "158"xsd:string |
| http://purl.uniprot.org/citations/8992987 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8992987 |
| http://purl.uniprot.org/citations/8992987 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8992987 |
| http://purl.uniprot.org/uniprot/#_P09838-mappedCitation-8992987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8992987 |
| http://purl.uniprot.org/uniprot/#_Q60517-mappedCitation-8992987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8992987 |
| http://purl.uniprot.org/uniprot/#_Q3UZ80-mappedCitation-8992987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8992987 |
| http://purl.uniprot.org/uniprot/P09838 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8992987 |
| http://purl.uniprot.org/uniprot/Q3UZ80 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8992987 |
| http://purl.uniprot.org/uniprot/Q60517 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8992987 |