| http://purl.uniprot.org/citations/8999919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8999919 | http://www.w3.org/2000/01/rdf-schema#comment | "Homeobox genes control the spatial identity and differentiation of tissues in the developing vertebrate embryo. Retinoids are signaling molecules involved in the regulation of Hox genes. We previously identified a 3' enhancer called the RAIDR5, which contained a DR5 retinoic acid response element (RARE) and was responsible for the retinoic acid (RA)-associated expression of the murine Hoxa-1 gene in teratocarcinoma cells. We demonstrate that a similar enhancer, which contains a DR5 RARE, is located at a DNase I-hypersensitive site 3' of the murine Hoxb-1 gene. This enhancer, the Hoxb-1 RAIDR5, regulates the RA responsiveness of the Hoxb-1 gene and is different in location and sequence from the RA-regulated 3' Hoxb-1 enhancers previously described. Several DNA elements within the murine Hoxa-1 RA-inducible RAIDR5 enhancer, including the DR5 RARE, conserved element (CE) 1, and CE2, are conserved in the murine Hoxb-1 RAIDR5 enhancer, the human homolog of Hoxa-1, and in the chicken Hoxb-1 gene. Gel shifts show that the CE2 sequence TATTTACTCA binds an RA-inducible factor, while UV cross-linking indicates that a 170-kDa protein binds to this sequence. Thus, the Hoxa-1 and Hoxb-1 genes possess 3' enhancers with similar sequences through which their expression and responsiveness to endogenous retinoids are controlled."xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.4.2167"xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/author | "Gudas L.J."xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/author | "Thompson J.R."xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/author | "Langston A.W."xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/pages | "2167-2175"xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/title | "Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis."xsd:string |
| http://purl.uniprot.org/citations/8999919 | http://purl.uniprot.org/core/volume | "272"xsd:string |
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