| http://purl.uniprot.org/citations/9006024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9006024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9006024 | http://www.w3.org/2000/01/rdf-schema#comment | "Two genes involved in the biosynthesis of the depsipeptide antibiotics pristinamycins I (PI) produced by Streptomyces pristinaespiralis were cloned and sequenced. The 1.7-kb snbA gene encodes a 3-hydroxypicolinic acid:AMP ligase, and the 7.7-kb snbC gene encodes PI synthetase 2, responsible for incorporating L-threonine and L-aminobutyric acid in the PI macrocycle. snbA and snbC, which encode the two first structural enzymes of PI synthesis, are not contiguous. Both genes are located in PI-specific transcriptional units, as disruption of one gene or the other led to PI-deficient strains producing normal levels of the polyunsaturated macrolactone antibiotic pristinamycin II, also produced by S. pristinaespiralis. Analysis of the deduced amino acid sequences showed that the SnbA protein is a member of the adenylate-forming enzyme superfamily and that the SnbC protein contains two amino acid-incorporating modules and a C-terminal epimerization domain. A model for the initiation of PI synthesis analogous to the established model of initiation of fatty acid synthesis is proposed."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.179.3.705-713.1997"xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Crouzet J."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Crouzet J."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "de Crecy-Lagard V."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "de Crecy-Lagard V."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Bamas-Jacques N."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Bamas-Jacques N."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Blanc V."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Blanc V."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Gil P."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Gil P."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Lorenzon S."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Lorenzon S."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Thibaut D."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Thibaut D."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Naudin L."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Naudin L."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Famechon A."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/author | "Famechon A."xsd:string |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9006024 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |