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http://purl.uniprot.org/citations/9006911http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9006911http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9006911http://www.w3.org/2000/01/rdf-schema#comment"Two genes encoding trehalose-6-phosphate synthase were cloned from Aspergillus niger. tpsA was cloned using the Saccharomyces cerevisiae GGS1/TPS1 gene as a probe. It encodes a 517-amino acid polypeptide with 64-70% similarity to trehalose-6-phosphate synthase of S. cerevisiae, Kluyveromyces lactis, and Schizosaccharomyces pombe. Its transcription occurs constitutively and is enhanced on carbon-derepressing carbon sources, coinciding with the presence of a CreA-binding nucleotide motif in the 5'-noncoding region of tpsA. Disruption of tpsA only weakly reduces growth on glucose, and neither influences the glucose induction of a low affinity glucose permease nor interferes with the catabolite repression of a pectinase; it causes reduced the heat tolerance of conidia. tpsB was cloned by a polymerase chain reaction-based strategy. Its 480 amino acid sequence showed 76.5% identity to tpsA. Its transcription was hardly detectable at ambient temperatures but was enhanced strongly upon heat shock, which agrees with the presence of several copies of a C4T stress-responsive element in its 5'-upstream sequences. Hence the function of yeast GGS1/TPS1 has been split into two differentially regulated genes in A. niger, of which none appears to be involved in glucose sensing."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.org/dc/terms/identifier"doi:10.1074/jbc.272.5.2729"xsd:string
http://purl.uniprot.org/citations/9006911http://purl.org/dc/terms/identifier"doi:10.1074/jbc.272.5.2729"xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/author"Kubicek C.P."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/author"Kubicek C.P."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/author"Wolschek M.F."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/author"Wolschek M.F."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/pages"2729-2735"xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/pages"2729-2735"xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/title"The filamentous fungus Aspergillus niger contains two 'differentially regulated' trehalose-6-phosphate synthase-encoding genes, tpsA and tpsB."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/title"The filamentous fungus Aspergillus niger contains two 'differentially regulated' trehalose-6-phosphate synthase-encoding genes, tpsA and tpsB."xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/volume"272"xsd:string
http://purl.uniprot.org/citations/9006911http://purl.uniprot.org/core/volume"272"xsd:string
http://purl.uniprot.org/citations/9006911http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9006911
http://purl.uniprot.org/citations/9006911http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9006911
http://purl.uniprot.org/citations/9006911http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9006911
http://purl.uniprot.org/citations/9006911http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9006911
http://purl.uniprot.org/uniprot/Q00217http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/9006911
http://purl.uniprot.org/uniprot/Q00075http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/9006911