| http://purl.uniprot.org/citations/9008707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9008707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9008707 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae cells select bud sites according to one of two predetermined patterns. MATa and MAT alpha cells bud in an axial pattern, and MATa/alpha cells bud in a bipolar pattern. These budding patterns are thought to depend on the placement of spatial cues at specific sites in the cell cortex. Because cytoskeletal elements play a role in organizing the cytoplasm and establishing distinct plasma membrane domains, they are well suited for positioning bud-site selection cues. Indeed, the septin-containing neck filaments are crucial for establishing the axial budding pattern characteristic of MATa and MAT alpha cells. In this study, we determined the budding patterns of cells carrying mutations in the actin gene or in genes encoding actin-associated proteins: MATa/alpha cells were defective in the bipolar budding pattern, but MATa and MAT alpha cells still exhibit a normal axial budding pattern. We also observed that MATa/alpha actin cytoskeleton mutant daughter cells correctly position their first bud at the distal pole of the cell, but mother cells position their buds randomly. The actin cytoskeleton therefore functions in generation of the bipolar budding pattern and is required specifically for proper selection of bud sites in mother MATa/alpha cells. These observations and the results of double mutant studies support the conclusion that different rules govern bud-site selection in mother and daughter MATa/alpha cells. A defective bipolar budding pattern did not preclude an sla2-6 mutant from undergoing pseudohyphal growth, highlighting the central role of daughter cell bud-site selection cues in the formation of pseudohyphae. Finally, by examining the budding patterns of mad2-1 mitotic checkpoint mutants treated with benomyl to depolymerize their microtubules, we confirmed and extended previous evidence indicating that microtubules do not function in axial or bipolar bud-site selection."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.136.1.111"xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.136.1.111"xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/author | "Drubin D.G."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/author | "Drubin D.G."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/author | "Ayscough K.R."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/author | "Ayscough K.R."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/pages | "111-123"xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/pages | "111-123"xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/title | "A role for the actin cytoskeleton of Saccharomyces cerevisiae in bipolar bud-site selection."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/title | "A role for the actin cytoskeleton of Saccharomyces cerevisiae in bipolar bud-site selection."xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/9008707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9008707 |
| http://purl.uniprot.org/citations/9008707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9008707 |
| http://purl.uniprot.org/citations/9008707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9008707 |
| http://purl.uniprot.org/citations/9008707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9008707 |