| http://purl.uniprot.org/citations/9008713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9008713 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF beta) is a dimeric peptide growth factor which regulates cellular differentiation and proliferation during development. Most cells secrete TGF beta as a large latent TGF beta complex containing mature TGF beta, latency associated peptide, and latent TGF beta-binding protein (LTBP)-1. The biological role of LTBP-1 in development remains unclear. Using a polyclonal antiserum specific for LTBP-1 (Ab39) and three-dimensional collagen gel culture assay of embryonic heart, we examined the tissue distribution of LTBP-1 and its functional role during the formation of endocardial cushion tissue in the mouse embryonic heart. Mature TGF beta protein was required at the onset of the endothelial-mesenchymal transformation to initiate endocardial cushion tissue formation. Double antibody staining showed that LTBP-1 colocalized with TGF beta 1 as an extracellular fibrillar structure surrounding the endocardial cushion mesenchymal cells. Immunogold electronmicroscopy showed that LTBP-1 localized to 40-100 nm extracellular fibrillar structure and 5-10-nm microfibrils. The anti-LTBP-1 antiserum (Ab39) inhibited the endothelial-mesenchymal transformation in atrio-ventricular endocardial cells cocultured with associated myocardium on a three-dimensional collagen gel lattice. This inhibitory effect was reversed by administration of mature TGF beta proteins in culture. These results suggest that LTBP-1 exists as an extracellular fibrillar structure and plays a role in the storage of TGF beta as a large latent TGF beta complex."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.136.1.193"xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/author | "Nakajima Y."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/author | "Nakamura H."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/author | "Yamagishi T."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/author | "Takase M."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/pages | "193-204"xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/title | "Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart."xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/9008713 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9008713 |
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