| http://purl.uniprot.org/citations/9015263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9015263 | http://www.w3.org/2000/01/rdf-schema#comment | "The translation of maternal glp-1 mRNA is regulated both temporally and spatially in the early Caenorhabditis elegans embryo (T. C. Evans, S. L. Crittenden, V. Kodoyianni, and J. Kimble, Cell 77, 183-194, 1994). To investigate the control of embryonic glp-1 expression, we have examined the distribution of GLP-1 protein in selected maternal effect mutants that affect pattern or fate in the early embryo. We find that mutants that disrupt anterior-posterior asymmetry in the early embryo (par-1-par-6, emb-8, Par(q537)) disrupt the spatial but not temporal control of GLP-1 expression: GLP-1 is observed at the normal stage of embryogenesis in par-like mutants; however, it is uniformly distributed. In contrast, mutants that alter blastomere identity (skn-1, pie-1, mex-1, apx-1) do not affect the normal GLP-1 pattern. We conclude that genes controlling the asymmetry of cellular components, including P granules, also control GLP-1 asymmetry in the early embryo. The finding that mutants that disrupt anterior-posterior asymmetry translate GLP-1 in all blastomeres suggests that loss of embryonic asymmetry causes translational activation of GLP-1 in the posterior."xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.1996.8413"xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/author | "Crittenden S.L."xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/author | "Evans T.C."xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/author | "Rudel D."xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/author | "Binder J."xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/pages | "36-46"xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/title | "Genes required for GLP-1 asymmetry in the early Caenorhabditis elegans embryo."xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/9015263 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9015263 |
| http://purl.uniprot.org/citations/9015263 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9015263 |
| http://purl.uniprot.org/uniprot/P13508#attribution-9FF2B22F65995B0C47428858CB96EDC0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9015263 |
| http://purl.uniprot.org/uniprot/#_P13508-mappedCitation-9015263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9015263 |
| http://purl.uniprot.org/uniprot/P13508 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9015263 |