| http://purl.uniprot.org/citations/9016654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9016654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9016654 | http://www.w3.org/2000/01/rdf-schema#comment | "Many of the vertebrate zinc finger factors of the Kruppel type (C2H2 zinc fingers) contain in their N-terminus a conserved sequence referred to as the KRAB (Kruppel-associated box) domain that, when tethered to DNA, efficiently represses transcription. Using the yeast two-hybrid system, we have isolated an 835 amino acid RING finger (C3HC4 zinc finger) protein, TIF1 beta (also named KAP-1), that specifically interacts with the KRAB domain of the human zinc finger factor KOX1/ZNF10. TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration). Like TIF1 alpha, TIF1 beta also contains an additional Cys/His cluster (PHD finger) and a bromo-related domain. When tethered to DNA, TIF1 beta can repress transcription in transiently transfected mammalian cells both from promoter-proximal and remote (enhancer) positions, similarly to the KRAB domain itself. We propose that TIF1 beta is a mediator of the transcriptional repression exerted by the KRAB domain."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/24.24.4859"xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/24.24.4859"xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "le Douarin B."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "le Douarin B."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Schaffner W."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Schaffner W."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Georgiev O."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Georgiev O."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Bourquin J.-P."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Bourquin J.-P."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Moosmann P.R."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/author | "Moosmann P.R."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/pages | "4859-4867"xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/pages | "4859-4867"xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/title | "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/title | "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1."xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/9016654 | http://purl.uniprot.org/core/volume | "24"xsd:string |