| http://purl.uniprot.org/citations/9017603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9017603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9017603 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the nuclear factor of activated T cells (NFAT) are involved in the induction of a number of cytokine genes. We report here cDNA cloning and chromosomal localization of a murine homologue of human NFATx, designated as mNFATx1, and its splicing variants mNFATx2 and m delta NFATx. Northern blot analysis showed mNFATx1 to be predominantly expressed in the thymus. mNFATx1, but not m delta NFATx, produced in COS-7 cells, bound to all NFAT-binding sites of the interleukin (IL)-2 and IL-4 promoters tested. Immunofluorescence assay showed that both mNFATx1 and m delta NFATx introduced into COS-7 cells localized predominantly to the cytoplasm, but did translocate to the nucleus, either by cotransfection with an active form of calcineurin or wild-type calcineurin followed by stimulation with calcium ionophore. Translocation of mNFATx1 correlated well with activation of the murine IL-2 promoter; mNFATx1 translocated under conditions described above, in combination with phorbol 12-myristate 13-acetate, activated the transiently transfected murine IL-2 promoter. Thus, nuclear-translocated mNFATx1 is involved in activation of the IL-2 promoter. These results provide the first evidence for the requirement of calcineurin in the control of mNFATx imported from the cytoplasm to the nucleus and implies that mNFATx may possibly be a substrate of calcineurin in vivo."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.8.1.157"xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.8.1.157"xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Arai K."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Arai K."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Imai S."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Imai S."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Takano T."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Takano T."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Ikeuchi T."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Ikeuchi T."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Arai N."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Arai N."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Saito-Ohara F."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Saito-Ohara F."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Koyano-Nakagawa N."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Koyano-Nakagawa N."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Amasaki Y."xsd:string |
| http://purl.uniprot.org/citations/9017603 | http://purl.uniprot.org/core/author | "Amasaki Y."xsd:string |