| http://purl.uniprot.org/citations/9020121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9020121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9020121 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucagon-like peptide 1 stimulates insulin secretion and inhibits glucagon secretion, gastric emptying, and feeding, suggesting it may be biologically useful for the treatment of diabetes. A lizard glucagon-like peptide 1 (GLP-1)-related peptide, exendin 4, binds to the GLP-1 receptor and mimics the actions of GLP-1 in vivo. To determine the genetic relationship between exendin 4 and GLP-1, we analyzed the structure and expression of pancreatic and intestinal proglucagon mRNAs in the reptile Heloderma suspectum. Two different proglucagon cDNAs (lizard proglucagon I (LPI) and lizard proglucagon II (LPII)), with unique 3'-untranslated regions were identified. Two LPI mRNA transcripts, approximately 1.6 and 2.1 kilobases, encoded glucagon and GLP-1 but not GLP-2 and were restricted in expression to the pancreas. In contrast, a 1.1-kilobase LPII mRNA transcript, encoding glucagon, GLP-1, and GLP-2 utilized a different 3'-untranslated region and was expressed in both pancreas and intestine. Lizard proglucagon mRNA transcripts were not detectable by reverse transcription-polymerase chain reaction or Northern blotting in salivary gland. A single class of lizard salivary gland proexendin cDNAs encoded the sequence of exendin 4 and a 45-amino acid exendin NH2-terminal peptide. Exendin mRNA transcripts were expressed in the salivary gland, but not pancreas or intestine. These data demonstrate that GLP-1 and exendin 4 represent related yet distinct peptides encoded by different genes in the lizard."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.7.4108"xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.7.4108"xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/author | "Chen Y.E."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/author | "Chen Y.E."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/author | "Drucker D.J."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/author | "Drucker D.J."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/pages | "4108-4115"xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/pages | "4108-4115"xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/title | "Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/title | "Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard."xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9020121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9020121 |
| http://purl.uniprot.org/citations/9020121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9020121 |
| http://purl.uniprot.org/citations/9020121 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9020121 |
| http://purl.uniprot.org/citations/9020121 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9020121 |
| http://purl.uniprot.org/uniprot/O12956 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9020121 |
| http://purl.uniprot.org/uniprot/P26349 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9020121 |