| http://purl.uniprot.org/citations/9032289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9032289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9032289 | http://www.w3.org/2000/01/rdf-schema#comment | "A functional approach to gene cloning was applied to HeLa cells in an attempt to isolate cDNA fragments which convey resistance to gamma interferon (IFN-gamma)-induced programmed cell death. One of the rescued cDNAs, described in this work, was a fragment of a novel gene, named DAP-5. Analysis of a DAP-5 full-length cDNA clone revealed that it codes for a 97-kDa protein that is highly homologous to eukaryotic translation initiation factor 4G (eIF4G, also known as p220). According to its deduced amino acid sequence, this novel protein lacks the N-terminal region of eIF4G responsible for association with the cap binding protein eIF4E. The N-terminal part of DAP-5 has 39% identity and 63% similarity to the central region of mammalian p220. Its C-terminal part is less homologous to the corresponding region of p220, suggesting that it may possess unique functional properties. The rescued DAP-5 cDNA fragment which conveyed resistance to IFN-gamma-induced cell death was expressed from the vector in the sense orientation. Intriguingly, it comprised part of the coding region which corresponds to the less conserved C-terminal part of DAP-5 and directed the synthesis of a 28-kDa miniprotein. The miniprotein exerted a dual effect on HeLa cells. Low levels of expression protected the cells from IFN-gamma-induced programmed cell death, while high levels of expression were not compatible with continuous cell growth. The relevance of DAP-5 protein to possible changes in a cell's translational machinery during programmed cell death and growth arrest is discussed."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.3.1615"xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.3.1615"xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Kimchi A."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Kimchi A."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Berissi H."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Berissi H."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Levy-Strumpf N."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Levy-Strumpf N."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Deiss L.P."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/author | "Deiss L.P."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/pages | "1615-1625"xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/pages | "1615-1625"xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/title | "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/title | "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9032289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9032289 |
| http://purl.uniprot.org/citations/9032289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9032289 |