| http://purl.uniprot.org/citations/9039941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9039941 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL) 6 is one of major mediators of inflammation, and IL-6 gene activation during hypoxia/reoxygenation has been implicated in the pathogenesis of ischemia/reperfusion injury. However, molecular events involved in IL-6 gene expression during hypoxia/reoxygenation remain to be identified. We have previously shown that NF-kappa B plays an essential and indispensable role in the transcriptional activation of the IL-6 gene induced by various stimuli, including IL-1 and tumor necrosis factor-alpha. We show here that hypoxia, but not reoxygenation, induces the activation of NF-kappa B through the degradation of a major inhibitor of NF-kappa B, I kappa B alpha. This hypoxia-induced NF-kappa B activation resulted in the kappa B-dependent transcriptional activation of the IL-6 gene. Interestingly, the time course of hypoxia-induced NF-kappa B activation was rather slow as compared with those of NF-kappa B activation induced by other stimuli, such as IL-1: a significant NF-kappa B activation was not observed before 1 hr of hypoxia treatment and persisted for up to 7 hr of hypoxia treatment. However, hypoxia-induced NF-kappa B activation was not inhibited by cycloheximide, which indicates that hypoxia directly triggers NF-kappa B activation. Furthermore, while hypoxia is unlikely to generate reactive oxygen intermediates, pretreatment of cells with antioxidants such as N-acetyl cysteine and alpha-tocopherol inhibited NF-kappa B activation induced by hypoxia. Thus, we discuss possible implications of these results for a postulated role of reactive oxygen intermediates in NF-kappa B activation."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.org/dc/terms/identifier | "doi:10.1097/00007890-199702150-00023"xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Hashimoto T."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Shimizu K."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Tani T."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Yagi M."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Yamamoto K."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Zhang Y.K."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Muraoka K."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/author | "Miyazaki I."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/name | "Transplantation"xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/pages | "466-470"xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/title | "Hypoxia, but not reoxygenation, induces interleukin 6 gene expression through NF-kappa B activation."xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/9039941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9039941 |
| http://purl.uniprot.org/citations/9039941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9039941 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-9039941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9039941 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-9039941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9039941 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-9039941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9039941 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFG1-mappedCitation-9039941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9039941 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFT1-mappedCitation-9039941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9039941 |
| http://purl.uniprot.org/uniprot/#_A2RTD1-mappedCitation-9039941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9039941 |