| http://purl.uniprot.org/citations/9045636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9045636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9045636 | http://www.w3.org/2000/01/rdf-schema#comment | "The Src family protein-tyrosine kinase, Fyn, is associated with the T cell receptor (TCR) and plays an important role in TCR-mediated signaling. We found that a human T cell leukemia virus type 1-infected T cell line, Hayai, overexpressed Fyn. To identify the molecules downstream of Fyn, we analyzed the tyrosine phosphorylation of cellular proteins in the cells. In Hayai, a 68-kDa protein was constitutively tyrosine-phosphorylated. The 68-kDa protein was coimmunoprecipitated with various signaling proteins such as phospholipase C gamma1, the phosphatidylinositol 3-kinase p85 subunit, Grb2, SHP-1, Cbl, and Jak3, implying that the protein might function as an adapter. Purification and microsequencing of this protein revealed that it was the RNA-binding protein, Sam68 (Src associated in mitosis, 68 kDa). Sam68 was associated with the Src homology 2 and 3 domains of Fyn and also those of another Src family kinase, Lck. CD3 cross-linking induced tyrosine phosphorylation of Sam68 in uninfected T cells. These data suggest that Sam68 participates in the signal transduction pathway downstream of TCR-coupled Src family kinases Fyn and Lck in lymphocytes, that is not only in the mitotic pathway downstream of c-Src in fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.10.6214"xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.10.6214"xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Iwamatsu A."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Iwamatsu A."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Fujisawa J."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Fujisawa J."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Iwashima M."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Iwashima M."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Fusaki N."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/author | "Fusaki N."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/pages | "6214-6219"xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/pages | "6214-6219"xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/title | "Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/title | "Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9045636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9045636 |
| http://purl.uniprot.org/citations/9045636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9045636 |