| http://purl.uniprot.org/citations/9054947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9054947 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute myeloid leukaemia (AML) is a major haematopoietic malignancy characterized by the proliferation of a malignant clone of myeloid progenitor cells. A reciprocal translocation, t(8;21)(q22;q22), observed in the leukaemic cells of approximately 40% of patients with the M2 subtype of AML disrupts both the AML1 (CBFA2) gene on chromosome 21 and the ETO (MTG8) gene on chromosome 8 (refs 3-5). A chimaeric protein is synthesized from one of the derivative chromosomes that contains the N terminus of the AML1 transcription factor, including its DNA-binding domain, fused to most of ETO, a protein of unknown function. We generated mice that mimic human t(8;21) with a "knock-in' strategy. Mice heterozygous for an AML1-ETO allele (AML1-ETO/+) die in midgestation from haemorrhaging in the central nervous system and exhibit a severe block in fetal liver haematopoiesis. This phenotype is very similar to that resulting from homozygous disruption of the AML1 (Cbfa2) or Cbfb genes, indicating that AML1-ETO blocks normal AML1 function. However, yolk sac cells from AML1-ETO/+ mice differentiated into macrophages in haematopoietic colony forming unit (CFU) assays, unlike Cbfa2-/- or Cbfb-/-cells, which form no colonies in vitro. This indicates that AML1-ETO may have other functions besides blocking wild-type AML1, a property that may be important in leukaemogenesis."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0397-303"xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Binder M."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Zhang D.E."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Sharpe A.H."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Yergeau D.A."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Speck N.A."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Marin-Padilla M."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/author | "Hetherington C.J."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/pages | "303-306"xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/title | "Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene."xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/9054947 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9054947 |
| http://purl.uniprot.org/citations/9054947 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9054947 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL0-mappedCitation-9054947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9054947 |
| http://purl.uniprot.org/uniprot/#_A0A087WR05-mappedCitation-9054947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9054947 |
| http://purl.uniprot.org/uniprot/#_Q08024-mappedCitation-9054947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9054947 |
| http://purl.uniprot.org/uniprot/#_G3UWD2-mappedCitation-9054947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9054947 |
| http://purl.uniprot.org/uniprot/#_G3X9W7-mappedCitation-9054947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9054947 |