| http://purl.uniprot.org/citations/9055855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9055855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9055855 | http://www.w3.org/2000/01/rdf-schema#comment | "Human herpesvirus-8 (HHV-8) has been detected in Kaposi's sarcoma (KS) lesions of all types (AIDS-related, classical and endemic), in body-cavity-based B-cell lymphomas (BCBLs) and in lesions of multicentric Castleman's disease (MCD). We have identified a major gamma-herpesvirus-divergent locus (DL-B) in HHV-8 DNA encoding several HHV-8 unique open reading frames (ORFs), including a homologue of interleukin-6 (IL-6) and two homologues of macrophage inflammatory protein MIP-1. We show that the HHV-8-encoded IL-6 homologue (vIL-6) shares functional properties with endogenous IL-6 proteins and that both vIL-6 and vMIP-1 transcripts are present at high levels following butyrate induction of an HHV-8' BCBL cell line. Low amounts of constitutive vIL-6, but not vMIP-1, mRNA were also detected. The presence of a functional IL-6 homologue encoded by HHV-8 may provide a mechanistic model for the hypothesized role of HHV-8 in KS, MCD and BCBL that involves the mitogenic effects of vIL-6 on surrounding cells. MIP-1 proteins may enhance these effects through the chemotactic recruitment of endogenous cytokine-producing cells into affected tissues and could potentially influence HIV disease progression in coinfected individuals through interactions with the HIV co-receptor CCR-5."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm0397-287"xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm0397-287"xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Hayward G.S."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Hayward G.S."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Nicholas J."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Nicholas J."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Guo H.G."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Guo H.G."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Reitz M.S."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Reitz M.S."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Wan X."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Wan X."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Ciufo D."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Ciufo D."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Burns W.H."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Burns W.H."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Ruvolo V.R."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Ruvolo V.R."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Sandford G."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Sandford G."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Hendrickson S.B."xsd:string |
| http://purl.uniprot.org/citations/9055855 | http://purl.uniprot.org/core/author | "Hendrickson S.B."xsd:string |