| http://purl.uniprot.org/citations/9060821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9060821 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysplastic colon adenomas are thought to arise from growth of clones of APC -/-colonic epithelial cells. Isolated clusters of dysplastic crypts are often observed in patients with familial adenomatous polyposis. These patients have genotype APC +/-, and the clusters of dysplastic crypts (called microadenoma or aberrant crypt foci) are thought to represent an early stage in the expansion of a mutant clone of APC -/-cells. It is thought that the growth of these clusters of mutant crypts results from crypt replication through a process similar to what occurs in the normal crypt cycle. We measured the relative replication rate of mutant crypts by analyzing the size of clusters of mutant crypts in APC +/-individuals and found that mutant APC -/-crypts replicate more rapidly than do normal APC +/-(i.e., nonneoplastic) crypts. In contrast, the replication rate of mutant crypts in Apc +/-mice is not significantly different from that of normal crypts, thus supporting previous findings that aberrant crypt foci do not contribute significantly to the colon adenoma population in adult Apc +/-mice. Intriguingly, we found an effect of Apc heterozygosity on the frequency of branching crypts in young mice."xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/author | "Cheng H."xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/author | "Gallinger S."xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/author | "Bjerknes M."xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/author | "Hay K."xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/pages | "833-839"xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/title | "APC mutation and the crypt cycle in murine and human intestine."xsd:string |
| http://purl.uniprot.org/citations/9060821 | http://purl.uniprot.org/core/volume | "150"xsd:string |
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