| http://purl.uniprot.org/citations/9062193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9062193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9062193 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 (IL-1) is an important mediator of inflammatory disease. The IL-1 family currently consists of two agonists, IL-1alpha and IL-1beta, and one antagonist, IL-1ra. Each of these molecules binds to the type I IL-1 receptor (IL1R). The binding of IL-1alpha or IL-1beta to IL1R is an early step in IL-1 signal transduction and blocking this interaction may therefore be a useful target for the development of new drugs. Here we report the three-dimensional structure of IL-1beta bound to the extracellular domain of IL1R (s-IL1R) at 2.5 A resolution. IL-1beta binds to s-IL1R with a 1:1 stoichiometry. The crystal structure shows that s-IL1R consists of three immunoglobulin-like domains which wrap around IL-1beta in a manner distinct from the structures of previously described cytokine-receptor complexes. The two receptor-binding regions on IL-1beta identified by site-directed mutagenesis both contact the receptor: one binds to the first two domains of the receptor, while the other binds exclusively to the third domain."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.org/dc/terms/identifier | "doi:10.1038/386190a0"xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.org/dc/terms/identifier | "doi:10.1038/386190a0"xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9062193 |
| http://purl.uniprot.org/citations/9062193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9062193 |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Anderson L.J."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Anderson L.J."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Brandhuber B.J."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Brandhuber B.J."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Caffes P."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Caffes P."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Vigers G.P.A."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/author | "Vigers G.P.A."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/pages | "190-194"xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/pages | "190-194"xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/title | "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/title | "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta."xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/volume | "386"xsd:string |
| http://purl.uniprot.org/citations/9062193 | http://purl.uniprot.org/core/volume | "386"xsd:string |