| http://purl.uniprot.org/citations/9062194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9062194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9062194 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammation, regardless of whether it is provoked by infection or by tissue damage, starts with the activation of macrophages which initiate a cascade of inflammatory responses by producing the cytokines interleukin-1 (IL-1) and tumour necrosis factor-alpha (ref. 1). Three naturally occurring ligands for the IL-1 receptor (IL1R) exist: the agonists IL-1alpha and IL-1beta and the IL-1-receptor antagonist IL1RA (ref. 2). IL-1 is the only cytokine for which a naturally occurring antagonist is known. Here we describe the crystal structure at 2.7 A resolution of the soluble extracellular part of type-I IL1R complexed with IL1RA. The receptor consists of three immunoglobulin-like domains. Domains 1 and 2 are tightly linked, but domain three is completely separate and connected by a flexible linker. Residues of all three domains contact the antagonist and include the five critical IL1RA residues which were identified by site-directed mutagenesis. A region that is important for biological function in IL-1beta, the 'receptor trigger site' is not in direct contact with the receptor in the IL1RA complex. Modelling studies suggest that this IL-1beta trigger site might induce a movement of domain 3."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.org/dc/terms/identifier | "doi:10.1038/386194a0"xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.org/dc/terms/identifier | "doi:10.1038/386194a0"xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Sarubbi E."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Sarubbi E."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Tardif C."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Tardif C."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Schreuder H."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Schreuder H."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Akeson A."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Akeson A."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Barrett R.W."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Barrett R.W."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Bowlin T."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Bowlin T."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Soffientini A."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Soffientini A."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Trump-Kallmeyer S."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Trump-Kallmeyer S."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Yanofsky S."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/author | "Yanofsky S."xsd:string |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9062194 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |