| http://purl.uniprot.org/citations/9065432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9065432 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 (IL-1) is a central mediator of the immune system involved in acute and chronic inflammatory responses. Although the sequences of two types of IL-1 receptors are known, the exact molecular events resulting in signal transduction and coupling to downstream signaling elements remain unclear. The recently cloned IL-1 receptor accessory protein (IL-1RAcP) has been suggested as a co-receptor molecule for IL-1RI, supported by the observation that its expression correlates to IL-1 responsiveness. We transfected the EL-4 subline D6/76 with IL-1RAcP cDNA. This cell line is an IL-1 non-responder expressing IL-1RI but lacking constitutive IL-1RAcP expression. The expression of IL-1RAcP in EL-4 D6/76 was sufficient to restore IL-1-induced activation of interleukin-1 receptor-associated kinase and of stress-activated protein kinases, translocation of the transcription factors NFkappaB and IL-1 NF to the nucleus, and induction of IL-2 mRNA synthesis. These results proved that IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.12.7727"xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/author | "Wesche H."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/author | "Kracht M."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/author | "Falk W."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/author | "Resch K."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/author | "Korherr C."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/author | "Martin M.U."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/pages | "7727-7731"xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/title | "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)."xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9065432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9065432 |
| http://purl.uniprot.org/citations/9065432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9065432 |
| http://purl.uniprot.org/uniprot/Q9NPH3#attribution-3B50395356793768EAEF2325D488CE57 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9065432 |
| http://purl.uniprot.org/uniprot/Q9NPH3#attribution-990A110EFE8B0FCF51F9FD17873F5D14 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9065432 |