| http://purl.uniprot.org/citations/9072969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9072969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9072969 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal transmission by many cell surface receptors results in the activation of phosphoinositide (PI) 3-kinases that phosphorylate the 3' position of polyphosphoinositides. From a screen for mouse proteins that bind phosphoinositides, the protein GRP1was identified. GRP1 binds phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4, 5)P3] through a pleckstrin homology (PH) domain and displays a region of high sequence similarity to the yeast Sec7 protein. The PH domain of the closely related protein cytohesin-1, which, through its Sec7 homology domain, regulates integrin beta2 and catalyzes guanine nucleotide exchange of the small guanine nucleotide-binding protein ARF1, was also found to specifically bind PtdIns(3,4,5)P3. GRP1 and cytohesin-1 appear to connect receptor-activated PI 3-kinase signaling pathways with proteins that mediate biological responses such as cell adhesion and membrane trafficking."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.275.5308.1927"xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.275.5308.1927"xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Czech M.P."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Czech M.P."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Chawla A."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Chawla A."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Guilherme A."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Guilherme A."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Virbasius J.V."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Virbasius J.V."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Holik J.J."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Holik J.J."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Klarlund J.K."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/author | "Klarlund J.K."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/pages | "1927-1930"xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/pages | "1927-1930"xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/title | "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains."xsd:string |
| http://purl.uniprot.org/citations/9072969 | http://purl.uniprot.org/core/title | "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains."xsd:string |