RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/9076683http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9076683http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9076683http://www.w3.org/2000/01/rdf-schema#comment"We report the characterization of two vertebrate homologs of Drosophila mothers against dpp (Mad) isolated from the mouse and the Xenopus embryo, named MusMLP (mad-like protein) and XenMLP, respectively, together with a summary of their expression patterns in the embryo. Overexpression of XenMLP causes ventralization of Xenopus embryos and we demonstrate that the C-terminal domain is necessary and sufficient to confer this biological effect. This domain also has the potential for transcriptional activation, as shown in one-hybrid assays in mammalian cells. We further demonstrate that MLPs are multidomain proteins by showing a cis-negative effect of the N-terminal domain on the transactivation by the C-terminal domain and that the proline-rich, middle domain maximizes the activity of the C-terminal domain. We also mapped the MusMLP gene to a region on mouse chromosome 13 that corresponds to a region on human chromosome 5q that contains cancer-related genes."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.org/dc/terms/identifier"doi:10.1016/s0925-4773(96)00629-6"xsd:string
http://purl.uniprot.org/citations/9076683http://purl.org/dc/terms/identifier"doi:10.1016/s0925-4773(96)00629-6"xsd:string
http://purl.uniprot.org/citations/9076683http://purl.org/dc/terms/identifier"doi:10.1016/S0925-4773(96)00629-6"xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Kozak C.A."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Kozak C.A."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Nelles L."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Nelles L."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Verschueren K."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Verschueren K."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Huylebroeck D."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Huylebroeck D."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Niehrs C."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Niehrs C."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Tylzanowski P."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Tylzanowski P."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Blumenstock C."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Blumenstock C."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Remacle J."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Remacle J."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Wuytens G."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Wuytens G."xsd:string
http://purl.uniprot.org/citations/9076683http://purl.uniprot.org/core/author"Kraft H."xsd:string